Cognitive Vitality Reports are reports written by neuroscientists at the Alzheimer's Drug Discovery Foundation (ADDF). These scientific reports include analysis of drugs, drugs-in-development, drug targets, supplements, nutraceuticals, food/drink, non-pharmacologic interventions, and risk factors. Neuroscientists evaluate the potential benefit (or harm) for brain health, as well as for age-related health concerns that can affect brain health (e.g., cardiovascular diseases, cancers, diabetes/metabolic syndrome). In addition, these reports include evaluation of safety data from clinical trials, if available, and from preclinical models.
Each report is available as a PDF to download. To view our official Ratings, click here.
Acarbose Download Allopregnanolone Download Ambrisentan Download AMX0035 Download Angiotensin II Receptor Blockers Download Anti-CD33 Download Anti-IL6 and IL6R mAbs Download Artesunate Download Aspirin low-dose NSAID Download Atomoxetine Download Bacillius Calmette-Guerin Vaccine Download Baricitinib Download Bempedoic acid Download Bisphosphonates Download Bumetanide Download Calcium Channel Blockers Download Cannabidiol Download Cilostazol Download Colchicine Low-dose Download COMT Inhibitors Download CSF-1R Inhibitors Download Dabigatran Download Daridorexant Download Dexmedetomidine Download DFMO Download Dimethyl Fumarate Download Donepezil Download DPP-4 Inhibitors Download Duloxetine Download Edaravone Download Efavirenz Download EPA Download Estetrol Download Etifoxine Download Fasudil Download Fenofibrate Download GLP-1 Receptor Agonists Download GM-CSF Download Guanfacine Download Hachimijiogan Download Hydroxychloroquine Download Ibrutinib Download Ibudilast Download Igmesine Download Ivermectin Download Iron Chelators Download IVIG Download Lamivudine Download Leflunomide & Teriflunomide Download Lenalidomide Download Levetiracetam Download Lithium (Microdoses) Download Lithium (Pharmaceutical) Download Maraviroc Download
Memantine Download Metformin Download Methotrexate Download Methylene Blue Download Minocycline Download Mirabegron Download Mirodenafil Download Modafinil Download Montelukast Download Nabilone Download Naltrexone low-dose Download Nicotine Download Nilotinib Download Nitazoxanide Download Nooept Download NSAID (Non-Aspirin) Download Omaveloxolone Download PDE5 Inhibitors Download Pemafibrate Download Pentoxifylline Download Pioglitazone Download Piracetam Download Ramelteon Download Rapamycin Download Rasagiline Download Retigabine Download Rhein Download Riluzole Download Rivastigmine Download Roflumilast Download Rolipram Download Rotigotine Download Selegiline Download Semaglutide Download Semax Download SGLT2 inhibitors Download Shingles vaccine Download Sodium Oligomannate (GV-971) Download Sodium Phenylbutyrate Download Sulfonylureas Download Sulodexide Download Suvorexant Download Tacrolimus Download Ticagrelor Download Trametinib Download Trazodone Download Valacyclovir Download Vorinostat Download Vortioxetine Download YangXue QingNao Download Zileuton Download
17α-Estradiol Download 2-Deoxy-D-Glucose Download 2-Hydroxybenzylamine Download 3K3A-Activated Protein C Download A3R Agonists Download AAV-hTERT Download Aha1 Inhibitors Download ALDH2 activators Download ALZ-801 Download Angiotensin 1-7 Download ANGPTL3-Targeted Therapies Download Anti-Atherosclerotic Nanoparticles Download Anti-C1q Download Anti-CD22 Download Anti-IL-11 Download Apabetalone Download Apilimod Download AR1001 Download AZ-67 Download Azeliragon Download Bardaloxone Methyl Download BIIB080 Download BMS-984923 (ALX-001) Download BPN14770 Download Bryostatin Download Buntanetap Download Calmodulin-like skin protein Download Cambinol Download CaMKK2 Inhibitors Download Carnosic acid Download Caspase 2 Inhibitors Download CETP Inhibitors Download cGAS-STING Download CK2 Inhibitors Download CP2 Download Crisdesalazine Download Cutamesine Download CSL112 Download CT1812 (Elayta) Download Cyclophilin Inhibitors Download Dapansutrile Download DHED Download Dihexa Download DYRK1A Inhibitors Download EC5026 Download EGX358 Download Elafibranor Download ENT1 inhibitors Download EP2 Antagonists Download Exosomes Download FGF21 Download Fibronectin-1 Inhibitors Download Fractalkine Modulators Download FSH blocking antibody Download Galectin-3 Inhibitors Download GDF-11 Download Gingipain Inhibitors Download Ginsenoside Rg1 Download Ginsenoside Rg3 Download Gintonin Download GPR39 Agonists Download HBX Download HDAC3 Inhibitors Download HDAC11 Inhibitors Download Homotaurine Download Hsp90 inhibitors Download Humanin and humanin analogs Download Hydrogen sulfide Download Hydroxypropyl-β-cyclodextrin Download IBC-Ab002 Download IGF1 Download Immunoproteasome Inhibitors Download Intranasal Glutathione Download Intranasal Insulin Download Intravenous Mesenchymal Stem Cells Download Irisin Download ISRIB Download J147 Download Klotho Download KPT-350 Download L3MBTL1 Inhibitors Download Ligustilide Download LINE1 Inhibition Download LM11A-31 (C-31) Download Lp(a) Download Lonafarnib Download Lrp1 Modulators Download LRRK2 Inhibitors Download LXR Agonists Download MANF Download
MARK4 Inhibitors Download MFGE8 Download Mitochondrial Transplantation Download MMF Prodrugs Download MOTS-c Download MP101/MP201 Download MSUT2 Inhibitors Download NE3107 (HE3286) Download Nicotinamide Mononucleotide Download NLRP3 Inhibitors Download NNI-362 Download Notum Inhibitors Download NPTX2 Modulator Download Nrf2 Activators Download Nrf2 PPI Inhibitors Download NSC001 Download NX210c Download O-GlcNAcase Inhibitors Download OGG1 Agonists Download Olamkicept Download ORM-12741 Download Osteocalcin Download P021 Download P110 Download P2X7R Inhibitors Download P2Y1R Inhibitors Download P2Y6R Agonist Download P38α MAPK Inhibitors Download PAR4 Antagonists Download Pepinemab Download Piromelatine Download Plasma exchange Download Pomaglumetad Download PPARδ Agonists Download Pridopidine Download Prosaposin Download PRX-03140 Download Psilocybin Download Rabeximod Download REST/NRSF Modulators Download RIPK1 Inhibitors Download Roluperidone Download RT001 Download RTA-405 Download S1P4R Antagonists Download S3QELs Download S6K1 Inhibitors Download SAGE-718 Download SBT-272 Download Senolytics Download SFX01 Download SHIP1 Modulators Download Simufilam (PTI-125) Download SKQ1 Download Small humanin-like peptides Download SPG-302 Download SS-31 Download Sterubin Download SXC-2023 Download Syk Inhibitors Download T regulatory cell Therapies Download T3D-959 Download Tanespimycin Download THIK-1 Inhibitors Download THN391 Download Thyromimetics Download TLR2 Inhibitors Download TLR4 Inhibitors Download Tramiprosate Download Traneurocin (NA-831) Download TRH Download Trichostatin-A Download Trodusquemine Download Troriluzole Download TRPM2 Inhibitors Download TRPML1 Agonists Download TQS-168 Download URMC-099 Download Vafidemstat (ORY-2001) Download Verdiperstat Download Volanesorsen Download VX-765 Download Xanamem Download XPro1595 Download
Acai Berries Download Blueberries Download Cocoa Download Green Tea Download Licorice Root Download Olive Oil Download Royal Jelly Download Stevia Download Wolffia globosa (Mankai) Download
Breathing Techniques Download Cold-water immersion Download CPAP for Obstructive Sleep Apnea Download Focused Ultrasound Download Inspiratory Muscle Strength Training Download Meditation Download Molecular Hydrogen Download Oxygen Nanobubbles Download Sauna Download Time-Restricted Eating Donwload Transcranial Direct Current Stimulation Download Transcranial Magnetic Stimulation Download Vagal Nerve Stimulation Download Whole Body Cryotherapy Download
AGE Download Air Pollution Download Aluminum Download Benzodiazepines Download Diphenhydramine Download Epigenetic Clocks Download Erythritol and Xylitol Download Mold and Mycotoxin Download Oxymetazoline Download Plastics Download Polygenic Risk Score Download Sleep (deficit/excess) Download Textile Toxins Download
7,8 Dihydroxyflavone Download Aged Garlic Extract Download Agmatine Download Alpha-GPC Download Alpha-ketoglutarate Download Apigenin Download Apoaequorin Download Astaxanthin Download Astragalus Download Bacopa Monnieri Download Benfotiamine Download Berberine Download Boswellia Download Centella Asiatica Download Centrophenoxine Download Citicoline Download Coffee Fruit Download Creatine Download Dihydromyricetin Download Dinh Lang Download D-serine Download EGCG Download Epithalamin & Epithalon Download Ergothioneine Download Fisetin Download Fucoidan Download Genistein Download Ginkgo biloba Download Glucosamine Download Honokiol Download Huperzine-A Download Kamikihito Download Krill Oil Download Licorice Flavonoids Download Lion's Mane Mushroom Download L-Serine Download L-Theanine Download Lysophosphatidylcholine-Omega3 Download Magnesium Download Medium Chain Triglycerides Download
Melatonin Download MitoQ Download N-Acetylcysteine Download NDGA Download Nicotinamide Riboside Download Omega-3 Fatty Acids Download Oxaloacetate Download Palmitoylethanolamide Download Panax Ginseng Download Pantethine Download PB125 Download Phosphatidylcholine & Lecithin Download Phosphatidylserine Download Plasmalogen Download Policosanol Download Polyamine Download Postbiotics Download Probiotics Download Protandim Download Pterostilbene Download PTI-00703 Download Resveratrol Download S-Adenosylmethionine Download S-equol Download Sage Download Selenium Download Shankhpushpi Download Silymarin Download Soy Isoflavones Download Sulforaphane Download Souvenaid Download Taurine Download Tauroursodeoxycholic Acid Download TA-65 Download Tinospora Cordifolia Download Trehalose Download Triphala Download Turkey Tail Mushrooms Download Urolithin A Download Ursolic Acid Download Vinpocetine Download Vitamin B6, B12, and Folate Download Vitamin K2 Download