OUR PORTFOLIO

Our portfolio includes grants and mission-related investments supporting Alzheimer’s drugs in development, biomarkers, prevention programs, and other projects designed to build the capacity of the field. You can explore the programs we have supported using the filter and “Search Database” options in the sidebar.

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Organization: Mayo Clinic Rochester

12 Projects | 6 Researchers | $3,013,985 Invested

2020

Mayo Clinic Rochester

Eugenia Trushina, PhD

Development of Small Molecules Modulators of Mitochondrial Function

  • Funding Amount: $600,000
  • Organization Type: Academic/Nonprofit
  • Program: Drug Discovery
  • Target: Mitochondria/Metabolic Function
  • Status: Closed

2018

Mayo Clinic Rochester

Clifford Jack, MD

Cerebrovascular Disease & Clinical Trials in AD: Cognitive Outcomes, Biomarker Outcomes, & Optimal Set of Features

  • Funding Amount: $499,143
  • Organization Type: Academic/Nonprofit
  • Program: Biomarkers
  • Target: Vascular
  • Status: Closed

2018

Mayo Clinic Rochester

Val Lowe, MD

Targeting Neuroinflammation as a Contributing Pathology in Alzheimer’s Disease Dementia

  • Funding Amount: $347,582
  • Organization Type: Academic/Nonprofit
  • Program: Biomarkers
  • Target: Neuroinflammation
  • Status: Active

2017

Mayo Clinic Rochester

Kejal Kantarci, MD, MS

Effects of Early Menopausal Hormone Therapy on Imaging Biomarkers of Cognitive Health

  • Funding Amount: $87,714
  • Organization Type: Academic/Nonprofit
  • Program: Prevention
  • Target: Endocrinology
  • Status: Closed

2017

Mayo Clinic Rochester

Eugenia Trushina, PhD

Small Molecule Inhibitors of Mitochondrial Complex I for Treatment of Alzheimer's Disease

  • Funding Amount: $600,000
  • Organization Type: Academic/Nonprofit
  • Program: Drug Discovery
  • Target: Mitochondria/Metabolic Function
  • Status: Closed

2015

Mayo Clinic Rochester

Eugenia Trushina, PhD

Lead Discovery of Novel Small Molecule Compounds Effective in Modulation of Mitochondrial Function

  • Funding Amount: $300,000
  • Organization Type: Academic/Nonprofit
  • Program: Drug Discovery
  • Target: Mitochondria/Metabolic Function
  • Status: Closed

2013

Mayo Clinic Rochester

Michelle Mielke, PhD

Evaluation of changes in plasma ceramides and amino compounds with an mTOT Modulator Insulin Sensitizer in AD patients

  • Funding Amount: $6,960
  • Organization Type: Academic/Nonprofit
  • Program: Biomarkers
  • Target: Mitochondria/Metabolic Function
  • Status: Closed

2013

Mayo Clinic Rochester

Eugenia Trushina, PhD

Lead Discovery of Novel Small Molecule Compounds Effective in Restoration of Mitochondrial Function-Year 2

  • Funding Amount: $140,000
  • Organization Type: Academic/Nonprofit
  • Program: Drug Discovery
  • Target: Mitochondria/Metabolic Function
  • Status: Closed

2012

Mayo Clinic Rochester

Michelle Mielke, PhD

Plasma lipidomic and alpha-synuclein comparison of individuals with alpha-synuclein, amyloid, or normal pathology

  • Funding Amount: $100,000
  • Organization Type: Academic/Nonprofit
  • Program: Biomarkers
  • Status: Closed

2012

Mayo Clinic Rochester

Eugenia Trushina, PhD

Mechanism of restoration of mitochondrial function by tricyclic pyrone compounds

  • Funding Amount: $181,757
  • Organization Type: Academic/Nonprofit
  • Program: Drug Discovery
  • Target: Mitochondria/Metabolic Function
  • Status: Closed
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