Despite the prevalence of Alzheimer's disease, the lack of an early and accurate diagnostic test remains a significant hindrance to the discovery of therapeutics. Our goal is to develop a screening tool for the early detection of Alzheimer's disease before symptoms are obvious. We have discovered proteins complexes in the blood that have the potential to provide an early diagnosis of Alzheimer's disease. We aim to develop new assays that are more sensitive and specific to than our current method for measuring these blood-based biomarkers. We will determine the diagnostic accuracy of the new methods with samples from the Australian Imaging and Biomarker Lifestyle study of ageing (AIBL), which is one of the largest studies of Alzheimer's disease in the world. Overall the information gained from this grant will help us uncover fundamental information about Alzheimer's disease.