(300 WORDS MAX.)Humanin (HN), a mitochondrial peptide, was discovered because it is enriched in a region of the brain which is resistant to Alzheimer's disease (AD). HN has since been found to protect isolated neurons against cell death induced by AD --related insults. It is able to improve the cognitive function of mice engineered to develop AD-like symptoms, and reverses the pathology in their brains. HN acts by preventing neurons from dying, in part by improving mitochondrial function, reducing inflammation, increasing their insulin sensitivity and decreasing oxidative stress. These processes all appear to have a role in AD progression, and so a molecule that targets all of these processes is highly attractive. To advance HN to the clinic, CohBar will identify and characterize highly potent variants of this peptide. We will identify variants which are more stable in people, and develop conditions and methods to deliver HN in a safe, reproducible, and efficacious way.