(300 WORDS MAX)Existing treatment of Alzheimer's disease utilizes medications that only ameliorate the symptoms and functioning of patients with AD, but are not curative, nor do they significantly change the course of the illness, in fact some of them also show undesirable side effects. Hence the design of safe medications that reinstate learning and memory is imperative for the treatment of Alzheimer's disease. The proposed research aids in the development of novel histone deacetylase 2 inhibitors that lack the zinc binding group. Such inhibitors are expected to have an improved toxicological profile and will be ideal for restoring long term memory in patients with dementia.