The Alzheimer’s Drug Discovery Foundation (ADDF) and Axxam SpA (Axxam) announced today that ADDF has awarded a follow-on grant to Axxam to further develop small molecule drugs to treat Alzheimer’s disease by targeting inflammation. This grant follows two previous awards by ADDF to Axxam in 2011 and 2013. The award will continue to fund a drug discovery project to identify compounds that selectively block the purinergic receptor, P2X7, which is involved in inflammation in the brain. Research activities under the previous grants have identified a new class of promising P2X7 selective antagonists that are currently under full expansion as well as lead compounds suitable for in vivo assessment in pharmacological models.
Today, the Alzheimer’s Drug Discovery Foundation (ADDF) and the Alzheimer’s Society UK announced new funding to explore the possibility of using a commonly prescribed drug which treats erectile dysfunction as the next treatment for dementia. Tadalafil – part of the same class of drugs as Viagra – is to be one of the major research programs funded by the two charities in a cross-Atlantic research partnership. This is the first ever study researching the use of an erectile dysfunction drug for vascular dementia.
On Monday, former model and restaurateur B. Smith was honored by the Alzheimer’s Drug Discovery Foundation (ADDF) at its Fifth Annual Fall Symposium & Luncheon “Hope on the Horizon” at The Pierre in New York City. Smith, who publicly revealed her early-onset Alzheimer’s diagnosis in June, was presented with The Charles Evans Award at Monday’s Luncheon for using her powerful platform to promote public awareness and raise critical funds to combat Alzheimer’s disease. Smith graciously accepted the award in a purple dress, the official color of d National Alzheimer’s Disease Awareness Month, with her husband and long-time business partner Dan Gasby by her side.
The Alzheimer’s Drug Discovery Foundation (ADDF) and OnDeckBiotech announced today the launch of ADDF ACCESS, a new and improved open access platform to connect scientists with a virtual network of contract research organizations (CROs), drug development experts and educational resources. By leveraging OnDeckBiotech’s cutting-edge technology, the enhanced ADDF ACCESS platform will streamline links between researchers and CROs specializing in diseases of the central nervous system (CNS) to expedite drug discovery research and development. The announcement came on day three of the ADDF’s 15th International Conference on Alzheimer’s Drug Discovery.
A new peer-reviewed publication from the Alzheimer’s Drug Discovery Foundation (ADDF) and The Michael J. Fox Foundation for Parkinson’s Research (MJFF) offers strategic insight on how philanthropy, industry and government organizations can advance repurposing of U.S. Food and Drug Administration (FDA)-approved drugs for the treatment of neurodegenerative diseases. The paper, published in the Annals of Clinical and Translational Neurology, was produced in collaboration with experts from these sectors and highlights the unique challenges and lack of commercial incentives for testing approved drugs in new disease indications, like Alzheimer’s or Parkinson’s disease, where they might be beneficial.
The Alzheimer’s Drug Discovery Foundation (ADDF) and OnDeckBiotech announced today a strategic partnership to provide a new platform technology for ADDF ACCESS. ADDF ACCESS is an open access database that provides a network of contract research organizations (CROs), drug development consultants and educational resources focused for diseases of the central nervous system (CNS). By leveraging OnDeckBiotech’s cutting-edge technology, ADDF ACCESS will increase the efficiency of contracting drug development services by scientists in academia and small biotechnology companies.
Researchers from The Ohio State (Columbus) and Emory (Atlanta) Universities will be the first recipients of drug discovery funding and innovation support from a new partnership between the Alzheimer's Drug Discovery Foundation (ADDF) and Harrington Discovery Institute (HDI) at University Hospitals Case Medical Center. The organizations will leverage their combined expertise and resources to advance highly promising Alzheimer's disease drug discovery projects conducted in academic medical institutions nationwide.
Drug Could Be the First to Slow the Progression of Alzheimer’s Disease
The Alzheimer’s Drug Discovery Foundation (ADDF) announced today that it raised more than $1.1 million in support of a clinical trial to test an existing drug for the treatment of Alzheimer’s disease. The $1.1 million was generated during the “Fund a Scientist” auction at its Eighth Annual Connoisseur’s Dinner on May 1, 2014, and awarded to Jeffrey Cummings, MD, director of the Cleveland Clinic Lou Ruvo Center for Brain Health in Las Vegas, Nevada and Cleveland, Ohio. Dr. Cummings will investigate rasagiline, an FDA-approved treatment for Parkinson’s disease with the potential to be the first drug to slow the course of Alzheimer’s disease.
Resource Will Provide Comprehensive Overview of the Science for Prevention Therapies
The Alzheimer’s Drug Discovery Foundation (ADDF) announced today the launch of Cognitive Vitality, a new online resource developed to provide a comprehensive and credible overview and analysis of the science for specific strategies to prevent Alzheimer’s and related dementias. The resource showcases the strength of the science for and against prevention strategies related to nutrition and the management of other diseases, to enable people to make informed decisions in protecting their brain from cognitive decline, Alzheimer’s and other dementias.
Outcomes Could Lead to Development of New and Cost-Effective Tools for Early Detection
The Alzheimer’s Disease and Dementia Initiative (ADDI) at the New York Academy of Sciences (the Academy) in partnership with the Alzheimer's Drug Discovery Foundation (ADDF), and with generous support by AstraZeneca, Janssen, Lilly, Merck, and Takeda, has awarded a $140,000 challenge grant to Blaine Roberts, PhD, Head of the Metalloproteomics Laboratory at The Florey Institute of Neuroscience and Mental Health in Australia. Dr. Roberts will be conducting research to validate a developmental blood test for Alzheimer’s disease.