Alzheimer’s Matters, the official blog of the ADDF, features insights, perspectives and commentary on current topics of interest in Alzheimer’s disease and related drug discovery.
The wire is buzzing with news that scientists have successfully modeled some of the key features of Alzheimer’s disease in a dish. The new technology, developed by a team of researchers at Massachusetts General Hospital (MGH) led by Rudolph E. Tanzi, may offer a more accurate, efficient and inexpensive way to screen prospective drugs for Alzheimer’s while also advancing our ability to understand the biological processes that lead to the disease.
Last week, The New York Times reported on new research revealing that a man without the APOE gene—a gene that helps to carry cholesterol and, in certain forms, dramatically increases a person’s risk of developing Alzheimer’s disease—was able to function normally. The news has important implications for Alzheimer’s research, suggesting that if scientists could develop therapies that inhibit the potentially toxic effects of APOE, patients could take the drug without fear of neurological complications.
By 2050, more than 1.5 billion people worldwide will be over the age of 65—triple the number of present-day seniors. And while the US ranks high on the aging populations’ scorecard, Japan, South Korea, Spain and Italy top the list. By midcentury, a third of their populations will be over 65.
Just 7 days left to register for our 15th International Conference on Alzheimer’s Drug Discovery at a special early bird rate! It’s a unique opportunity to join leaders in academic and industry to learn about the latest developments in Alzheimer’s drug discovery research at a fraction of the ordinary registration costs. Need more convincing? Here are the top 5 reasons to join us on September 8th and 9th in Jersey City, NJ, for our 15th International Conference on Alzheimer’s Drug Discovery!
Did you miss news from the 2014 Alzheimer’s Association International Conference (AAIC) in Copenhagen, Denmark? Not to worry—our team of neuroscientists was there in full force, and now they’re sharing highlights from their favorite sessions on our blog.
With practical advice for caregivers, important information about the state of Alzheimer’s research and a moving record of her life after losing a loved one to the disease, Joan Sutton’s powerful new memoir is at once distinctive, instructive and deeply relatable. It's a must-read for anyone who has been affected by Alzheimer's disease.
Researchers funded by the Alzheimer’s Drug Discovery Foundation have identified a promising new drug that prevents the formation of abnormal blood clots in the brain, reduces cerebral inflammation and improves memory in mice with Alzheimer’s disease. The drug, RU-505, is a synthetic compound identified from an initial pool of nearly 95,000 drug candidates.
A century after Alois Alzheimer described a "peculiar case" of presenile dementia, researchers know more than ever before about the biology of aging and Alzheimer’s disease. But despite incredible progress, more than 59 percent of adults still believe that Alzheimer’s disease is a typical part of aging. This widespread misconception means that many individuals are going undiagnosed and untreated, and that crucial research towards a cure is going unfunded.
My husband and I had been together 26 years when he became one of nearly six million North Americans diagnosed with Alzheimer’s disease. Seven years later, I was an Alzheimer’s widow. As useful as support groups, information booklets and other sources of information were, what I wanted more than anything during those seven years as a caregiver was a drug that would alter the course of the disease. But there is no drug that will stop Alzheimer’s from progressing. There is no cure. And there are no survivors.
The search for drugs that slow or stop the progression of Alzheimer’s disease is no small task. That’s why the Alzheimer’s Drug Discovery Foundation has long collaborated with a diverse group of public and private sector partners—like the National Institute on Aging, Merck and The Association for Frontotemporal Degeneration—to leverage our collective knowledge, experience and funding power. Our latest collaboration, the Accelerating Medicines Partnership (AMP), is one of the most exciting examples to date.