A common antidepressant can dramatically halt growth of Alzheimer’s plaque. A team from Missouri and Pennsylvania report today in Science Translational Medicine this reduction occurs in both humans and mice. It gives the drug, the selective serotonin reuptake inhibitor (SSRI) citalopram, a possible future role as a prophylactic—the first in Alzheimer’s disease (AD), if bigger studies are supportive. “I think this is an important paper,” Howard Fillit said in an interview with Bioscience Technology. Fillit is [executive director and] chief scientific officer of the Alzheimer’s Drug Discovery Foundation. He offered a corollary, however, given that a small February JAMA study, while “exciting,” did find citalopram may cause cognitive problems after AD onset: “The biology of SSRIs is really interesting. But we have cured mice of Alzheimer’s 400 times. I hope this leads to a Phase 2b or 3 study, to look at whether citalopram and other SSRIs can be disease-modifying agents for AD.”
The Alzheimer’s Drug Discovery Foundation (ADDF) has announced it has raised more than $1.1 million for a clinical trial that will test the ability of existing drug rasagiline to treat Alzheimer’s. The funds were raised by an auction at the Eighth Annual Connoisseur’s Dinner. In all, the dinner raised over $3.5 million for drug research related to Alzheimer’s disease. Rasagiline, which is produced by Teva, is currently approved by the FDA to treat Parkinson’s disease. The clinical research will be led by Jeffrey Cummings, who is the director of the Cleveland Clinic Lou Ruvo Center for Brain Health in Las Vegas, Nevada and Cleveland, Ohio
Last Thursday night I went down to Sotheby’s for a black tie dinner benefiting the Alzheimer’s Drug Discovery Foundation. ADDF was created in 1998 by Leonard and Ronald Lauder, sons of Estee. In the past eight years they’ve established a public profile.
The Alzheimer's Drug Discovery Foundation (ADDF) announced today that it raised more than $1.1 million in support of a clinical trial to test an existing drug for the treatment of Alzheimer's disease. The $1.1 million was generated during the "Fund a Scientist" auction at its Eighth Annual Connoisseur's Dinner and awarded to Jeffrey Cummings, director of the Cleveland Clinic Lou Ruvo Center for Brain Health in Las Vegas, Nev. and Cleveland, Ohio. Cummings will investigate rasagiline, an FDA-approved treatment for Parkinson's disease with the potential to be the first drug to slow the course of Alzheimer's disease.
Moralioglu, who made his inaugural visit to Washington to show his Fall/Winter 2014 collection at the Alzheimer’s Drug Discovery Foundation’s annual Great Ladies Luncheon and Fashion Show, also managed to fit in visits to the Lincoln Memorial, the White House, the POV at the W Hotel and the National Cathedral. But WL snagged 10 minutes of his time on his last day in the city to chat about where he gets his inspiration for his designs, why he is fascinated by the “codes of femininity,” his ideal woman client and what real-life woman has had the biggest influence on him.
Alzheimer’s disease presents researchers with a number of challenges, from the difficulties in early detection and treatment to the trouble in securing adequate funding for research. The Alzheimer’s Drug Discovery Foundation (ADDF), whose “mission is to rapidly accelerate the discovery of drugs to prevent, treat and cure Alzheimer’s,” provides seed funding for early-stage research at Alzheimer’s drug discovery programs around the world. We had the pleasure of speaking with Penny Dacks, Assistant Director of Aging and Alzheimer’s Prevention at the ADDF, about what the foundation does, the challenges they face and some of the exciting new drug research they’re helping make possible.
The Alzheimer’s Drug Discovery Foundation is a biomedical venture philanthropy nonprofit aimed at developing treatments, and eventually a cure, through a diverse portfolio of programs. The ADDF focuses its funding on early-stage research and clinical trials to reduce the financial barriers that prevent promising medications from reaching the public. Many of its grants are structured as investments; the returns are then directed toward new research. The ADDF partners with Merck, Pfizer, and others. It funded early research for what became Amyvid, a diagnostic test for Alzheimer’s disease that was approved by the FDA in 2012.
The Lady Vol and winningest coach in NCAA history took time out from March Madness to visit Washington on Tuesday, where she lunched with some of the city’s most fashionable donors. The Alzheimer’s Drug Discovery Foundation honored Summitt, calling her “an inspiration to us all,” for her work with her own foundation, which she founded in 2011 after announcing she had been diagnosed with early-onset Alzheimer’s.
Fisetin, a flavonol found in strawberries, mangoes, cucumber, and other fruits and vegetables, may protect the brain against Alzheimer’s, dementia, and age-related memory loss, according to research just out from the Salk Institute for Biological Studies.
We’ve known for years that the number of deaths caused by Alzheimer’s disease and related dementias have been underreported, but a recent study identified the disease as the potential third-leading cause of death in the U.S. after heart disease and cancer. The study, published last week in the journal Neurology, found that the number of people who die from Alzheimer’s may be five times higher than previously thought, partly because death certificates often fail to list Alzheimer’s as a contributing cause of death. But this is only part of the story. The problems begin many years before death, when the disease is in its earliest stages.